Novel Blood Biomarkers for a Diagnostic Workup of Acute Aortic Dissection
نویسندگان
چکیده
Acute aortic dissection (AAD) is a rare condition, but together with acute myocardial infarction (AMI) and pulmonary embolism (PE) it belongs to the most relevant life-threatening causes of chest pain. Until now, there has been no specific blood test in diagnostic workup AAD. To identify clinically biomarkers for AAD, we applied Proseek® Multiplex assays plasma samples from patients AMI, PE, thoracic aneurysm (TAA), non-cardiovascular pain (nonCVD). Subsequently, validated top hits using conventional immunoassays examined their expression tissue. Interleukin 10 (IL-10) alone showed best performance sensitivity 55% specificity 98% AAD diagnosis. The combination D-dimers, high-sensitive troponin T (hs-TnT), interleukin 6 (IL-6), plasminogen activator inhibitor 1 (PAI1) correctly classified 75% cases, delivering 83% 95% its Moreover, this model provided correct classification 77% all analyzed cases. Our data suggest that IL-10 shows potential be rule-in biomarker addition PAI1 IL-6 hs-TnT D-dimers may improve discrimination suspected PE presenting
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ژورنال
عنوان ژورنال: Diagnostics
سال: 2021
ISSN: ['2075-4418']
DOI: https://doi.org/10.3390/diagnostics11040615